Mechanisms of contextual regulation of behavior
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We have shown that inputs converging on the nucleus accumbens are critical for the rapid modulation of motivation. We are interested in exploring how defined inputs and outputs of the nucleus accumbens are involved in this process. We are making use of multisite electrophysiology, targeted optogenetic manipulations, and novel behavioral preparations to address the ability of this region to flexibly drive behavior.
Relating neural heterogeneity to behavioral processes
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A primary focus of the lab is to understand the function of different striatal regions in contributing to motivated behavior. We are particularly interested in how this homogeneously composed brain structure performs heterogeneous functions, with regions only a millimeter apart having disparate functions. For instance, we focus on how neuromodulators like dopamine or acetylcholine help construct and shape such heterogeneity.